CD14 is a coreceptor of Toll-like receptors 7 and 9
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چکیده
منابع مشابه
CD14 is a coreceptor of Toll-like receptors 7 and 9
Recognition of pathogens by the innate immune system requires proteins that detect conserved molecular patterns. Nucleic acids are recognized by cytoplasmic sensors as well as by endosomal Toll-like receptors (TLRs). It has become evident that TLRs require additional proteins to be activated by their respective ligands. In this study, we show that CD14 (cluster of differentiation 14) constituti...
متن کاملCD 14 is a coreceptor of Toll - like receptors 7 and 9 Christoph
The Rockefeller University Press $30.00 J. Exp. Med. Vol. 207 No. 12 2689-2701 www.jem.org/cgi/doi/10.1084/jem.20101111 2689 Pattern recognition receptors are used by cells to scan for intruding pathogens. Whereas a series of pattern recognition receptors like RIG-I–like helicases and NOD-like receptors are present in the cytoplasm, Toll-like receptors (TLRs) are transmembrane proteins associat...
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TLRs (Toll-like receptors) are a family of innate immune receptors that induce protective immune responses against infections. Single-stranded viral RNA and bacterial DNA containing unmethylated CpG motifs are the ligands for TLR7 and TLR8 and 9 respectively. We have carried out extensive structure-activity relationship studies of DNA- and RNA-based compounds to elucidate the impact of nucleoti...
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Female and male reproductive tracts are of interest sites to study of immune system because they encounter specific infections such as those are sexually transmitted. Furthermore, female reproductive tract is in close contact with allogenic sperms and transmitted microorganisms during intercourse and semi allogenic fetus during pregnancy. In mammals, there are two types of immune responses, the...
متن کاملThe expression of Toll-like receptors 2, 4, 5, 7 and 9 in Merkel cell carcinoma.
AIM We sought to clarify whether the expression of toll-like receptors (TLR) in Merkel cell carcinoma (MCC) is linked to tumor and patient characteristics, especially the presence of Merkel cell polyoma virus (MCV). MATERIALS AND METHODS The study comprised of 128 patients with data on Merkel cell polyomavirus (MCV) status and clinical features were included in the study. Immunohistochemistry...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2010
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20101111